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M F

Mario Alberto Flores-Valdez

0000-0002-4125-1370

Employment

OrganisationRoleDepartmentStart dateEnd date
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoInvestigador Titular C/Principal Investigator Not specified2007-12-17

Education

OrganisationDegree/titleDepartmentStart dateEnd date
Stanford University School of MedicinePostdoctoral fellowNot specified2004-09-012007-08-31
Universidad Nacional Autónoma de MéxicoDoctor en Ciencias BioquímicasNot specified1999-08-012003-08-30
Universidad Autónoma de Nuevo LeónMaestro en Ciencias Biología Molecular e Ingeniería GenéticaNot specified1996-09-011999-05-30
Universidad de Sonora División de Ciencias Biológicas y de la SaludQuímico BiólogoNot specified1991-09-011996-06-30

Works

TitleDOIPublished date
Genome sequences of BCG Pasteur ATCC 35734 and its derivative, the vaccine candidate BCGΔBCG1419c.10.1186/s12864-023-09169-92023-02-10
Recent Developments in Mycobacteria-Based Live Attenuated Vaccine Candidates for Tuberculosis10.3390/biomedicines101127492022-10-29
Human Pulmonary Tuberculosis: Understanding the Immune Response in the Bronchoalveolar System10.3390/biom120811482022-08-20
BCG and BCGΔBCG1419c transiently protect hypersusceptible I/St mice and induce different influx of macrophages and neutrophils during pulmonary tuberculosis10.1099/jmm.0.0014852022-01-18
Biofilms in tuberculosis: What have we learnt in the past decade and what is still unexplored?10.1016/j.tube.2021.1021532022-01
BCGΔBCG1419c increased memory CD8<sup>+</sup> T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis10.1038/s41598-022-20017-w2022
Construction of Novel Live Genetically Modified BCG Vaccine Candidates Using Recombineering Tools10.1007/978-1-0716-1884-4_192022
Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c10.1038/s41598-022-14935-y2022
Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates10.1016/B978-0-323-91948-7.00013-02022
After 100 Years of BCG Immunization against Tuberculosis, What Is New and Still Outstanding for This Vaccine?10.3390/vaccines100100572021-12
New Insights into the Methylation of <i>Mycobacterium tuberculosis</i> Heparin Binding Hemagglutinin Adhesin Expressed in <i>Rhodococcus erythropolis</i>10.3390/pathogens100911392021-09
Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG.10.1038/s41598-021-91993-82021-06-14
Proteomic characterization of a second-generation version of the BCGΔBCG1419c vaccine candidate by means of electrospray-ionization quadrupole time-of-flight mass spectrometry10.1093/femspd/ftaa0702021-01-16
Preclinical evaluation of tuberculosis vaccine candidates: Is it time to harmonize study design and readouts for prioritizing their development?10.1016/j.vaccine.2020.11.0732020-12-14
Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication10.1016/j.tube.2020.1020052020-12
Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment10.1038/s41598-020-69152-22020-12
Author Correction: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines10.1038/s41541-020-00250-y2020-10-20
Transcriptional and Mycolic Acid Profiling in Mycobacterium bovis BCG In Vitro Show an Effect for c-di-GMP and Overlap Between Dormancy and Biofilms10.4014/jmb.1911.110432020-06-28
BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines10.1038/s41541-020-0169-62020-03-12
Can immunization with Bacillus Calmette-Guérin be improved for prevention or therapy and elimination of chronic Mycobacterium tuberculosis infection?10.1080/14760584.2019.17042632019-12-02
Macrophage infection with combinations of BCG mutants reduces induction of TNF-α, IL-6, IL-1β and increases IL-410.1016/j.tube.2019.01.0052019-03
Advanced hydrogels for treatment of diabetes10.1002/term.28802019
BCG vaccination prevents reactivation of latent lymphatic murine tuberculosis independently of CD4<sup>+</sup> T cells10.3389/fimmu.2019.005322019
Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia10.3389/fcimb.2019.003422019
New potential biomarkers to assess efficacy of protection afforded by vaccine candidates against tuberculosis10.1016/j.cmi.2019.02.0102019
BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice10.1016/j.tube.2018.08.0122018-12
Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of M. tuberculosis to the spleen10.1093/femspd/fty0882018-11-30
Modulation of autophagy as a strategy for development of new vaccine candidates against tuberculosis10.1016/j.molimm.2018.03.0062018-05
An opportunity to compare the effects of BCGMoreau and BCG-Russia in Brazil10.5588/ijtld.18.02712018
Evaluation of the immunogenic capability of the BCG strains BCGΔBCG1419c and BCGΔBCG1416c in a three-dimensional human lung tissue model10.1016/j.vaccine.2018.02.0442018
Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence10.1016/j.vaccine.2018.03.0142018
The BCGΔBCG1419c vaccine candidate reduces lung pathology, IL-6, TNF-α, and IL-10 during chronic TB infection10.3389/fmicb.2018.012812018
Mice continue to be a good model for preliminary assessment of tuberculosis vaccine candidates10.1080/21645515.2016.12480102017
Recent mouse models and vaccine candidates for preventing chronic/latent tuberculosis infection and its reactivation10.1093/femspd/ftx0792017
Uncovering the hidden: complexity and strategies for diagnosing latent tuberculosis10.15698/mic2017.11.5962017
A quantitative model for dermal infection and oedema in BALB/c mice pinna10.1186/s12866-016-0907-02016
Multiantigenic subunitary vaccines against tuberculosis in clinical trials: Where do we stand and where do we need to go?10.1080/21645515.2015.11367602016
The BCGΔBCG1419c strain, which produces more pellicle in vitro, improves control of chronic tuberculosis in vivo10.1016/j.vaccine.2016.08.0352016
Vaccines directed against microorganisms or their products present during biofilm lifestyle: Can we make a translation as a broad biological model to tuberculosis?10.3389/fmicb.2016.000142016
Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages10.1007/s13213-014-0910-32015
The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG10.1007/s12223-014-0335-12015
The cyclic di-GMP phosphodiesterase gene Rv1357c/BCG1419c affects BCG Pellicle production and in Vivo maintenance10.1002/iub.13532015
Current approaches and models to develop and evaluate new vaccines and drugs against tuberculosisNo DOI available.2014
Formation of mycobacterial pellicles in vitro and their possible impact on tuberculosis infection10.2174/1573398X106661407171856302014
OmpR phosphorylation regulates ompS1 expression by differentially controlling the use of promoters10.1099/mic.0.071381-02014
A DNA vaccine containing PPE68 induces humoral response in cattleNo DOI available.2013
Expression of non-replicating persistence associated genes of Mycobacterium bovis in lymph nodes from skin test-reactor cattle10.1016/j.micpath.2013.04.0122013
Extensively drug-resistant tuberculosis (XDR-TB): Successful therapies used in the clinic to the disease,Tuberculosis extensamente resistente a antibióticos (TB-XDR): Terapias utilizadas con éxito en la clínica para curar la enfermedadNo DOI available.2013
Mycobacterium bovis DNA detection in colostrum as a potential indicator of vaccination effectiveness against bovine tuberculosis10.1128/CVI.00566-122013
The synthetic cathelicidin HHC-10 inhibits mycobacterium bovis BCG in vitro and in C57BL/6 mice10.1089/mdr.2012.01492013
Transient expression and characterization of the antimicrobial peptide protegrin-1 in Nicotiana tabacum for control of bacterial and fungal mammalian pathogens10.1007/s11240-013-0344-92013
Mycobacterium Tuberculosis Signaling via c-AMPNo DOI available.2012
Vaccination of mice with recombinant bacille Calmette-Guérin harboring Rv1357c protects similarly to native BCG10.5588/ijtld.11.07352012
Identification of immunodominant antigens of Mycobacterium bovis by expression library immunization10.1016/j.tvjl.2010.09.0212011
Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcriptionNo DOI available.2011
Distribution of multidrug resistant bacteria in inanimate objects within stalls in Hidalgo, Mexico10.3923/javaa.2010.3008.30102010
DosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions10.1016/j.tube.2010.04.0012010
Global reemergence of tuberculosis: Are host defense peptides an option to ameliorate disease burden?10.1089/mdr.2009.00872010
Modulation of cAMP metabolism in Mycobacterium tuberculosis and its effect on host infection10.1016/j.tube.2010.03.0022010
Molecular findings and approaches spotlighting Mycobacterium bovis persistence in cattle10.1051/vetres/20090052009
Mycobacterium tuberculosis modulates its cell surface via an oligopeptide permease (Opp) transport system10.1096/fj.09-1324072009
LeuO antagonizes H-NS and StpA-dependent repression in Salmonella enterica ompS110.1111/j.1365-2958.2007.05958.x2007
A positive regulatory loop controls expression of the locus of enterocyte effacement-encoded regulators Ler and GrlA10.1128/JB.187.23.7918-7930.20052005
Negative Osmoregulation of the Salmonella ompS1 Porin Gene Independently of OmpR in an hns Background10.1128/JB.185.22.6497-6506.20032003

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